International Journal of Surgery and Surgical Sciences (IJSSS)
Open Access
Subscription Access
PREVALENCE OF HELICOBACTER PYLORI IN PATIENTS WITH PEPTIC ULCER DISEASE UNDERGOING UPPER G.I. ENDOSCOPY IN KIMS HOSPITAL
Abstract
Introduction: Helicobacter pylori (H Pylori) infection occurs worldwide, affecting more than half of the world population.
Materials & Methods: This is time bound prospective study done in 155 patients diagnosed to have peptic ulcer disease by UGIE in KIMS hospital were taken in to study. The study was from December 2013 to May 2015. The biopsy specimens were instantly inoculated into the H Pylori kit. Positive test for H Pylori was shown by change in colour of the medium from yellow to pink or red. The other two biopsy specimens were sent for routine histopathology and staining with Giemsa stain. The case was taken as H. pylori positive when the rapid urease test and/ or histopathological examination was positive.
Results: Out of 155 patients, 123 patients were diagnosed to have been infected with H. pylori infection(79%).Out of 155 the duodenal ulcer were present in 111 patients and gastric ulcer were present in 44 patients. Out of 111 duodenal ulcer patients H. pylori positive are 92(84%) and out of 44 gastric ulcer patients H. pylori positive are 31(70%).
Conclusion: In this study, we found that in peptic ulcer disease, H Pylori was consistently associated and its well proved with various studies done in past and present. Thus, we conclude H Pylori infection definitely have role in the etiopathogenesis of peptic ulcer disease. The study also provides information that H Pylori is more common in rural and lower socioeconomic group. Hence, we recommend eradication of the bacteria only in patients positive for the bacterium, who have peptic ulcer disease. Our study implies that H. pylori infection has an overall prevalence of around 79% in ulcer patients in our KIMS hospital. Its presence is more with ulcerative dyspepsia patients. And its prevalence increases with age.
Keywords
References
Ahuja V. (2006). “The case of h.pylori eradication in india: sensationalism, skepticism and scientific salesmanship”, Indian journal of gastroenterology, Vol.25, pp.20-24.
Brock J, Sauaia A, and Ahnen D et al. (2001). “Process of care and outcome for elderly patients hospitalized with peptic ulcer disease”, JAMA, Vol.286(16), available online: http://jamanetwork.com/journals/jama/fullarticle/194313
Doenges JL. (1938). “Spirochaetes in gastric glands of macacus rhesus and humans without definite history of related disease”, ProcSocExpBiol Med, Vol.38, pp.536-538.
Forman D, Newel DG, Fullerton F, and Yarnell JWG, et al. (1991). “Association between infection with h. pylori and risk of gastric cancer: evidence from prospective investigation”, BMJ, Vol.302, pp.1302-1305, available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1670011/pdf/bmj00128-0020.pdf
Freedburg AS, and Barron LE. (1940). “The presence of spirochaetes in humanvgastric mucosa”, Am. J. Dig Dis, Vol.7, pp.443-445.
Freston JW. (2000). “Helicobacter pylori-negative peptic ulcers: frequency and implications for management”, Journal of Gastroenterology, Vol.35(12), pp.29-32.
Ghosal UC, Singh R, Chang FY, and Hou X, et al. (2011). “Epidemology of Uninvestigated and Functional Dyspepsia in Asia: Facts and Fiction”, J Neurogastroenterol Motil, Vol.17(3), pp.235-244, available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155059/.
Goodwin CS, Armstrong JA, and, Marshall BJ. (1986). “Campylobacter pyloridis, gastritis and peptic ulceration”, J clinic Pathol, Vol.39(4), pp.353-365, available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC499829/.
Goodwin CS, and Worsley BW. (1993). “Microbiology of Helicobacter pylori”, Gastroenterology Clinics of North America, Vol.22(1), pp.5-19.
Holle GE. (2010). Pathophysiology and modern treatment of ulcer disease”, INT J MOL. MED, Vol.25, pp.483-491.
Jain A, and Buddhiraja S, et al. (1999). “Risk factors for duodenal ulcers in North India”, Tropical Gastroenterology, Jan-Mar, Vol.20(1), pp.36-39.
Kidd M, and Louw JA et al. (1999). “Helicobacter pylori in Africa: Observations on an ‘Enigma within an enigma’”, Journal of Gastroenterology & Hepatology, Sept, Vol.14(9), pp.851-858.
Kretsinger K, Sobel J, Tarkhashvili N, Chakvetadze N, Moistrafishvili M, and Sikharulidze M, et al. (2005). “Helicobacter pylori, Republic of Georgia [letter]”, Emerg Infect Dis [serial on the Internet], available online: http://dx.doi.org/10.3201/eid1105.040755
Leong RW. (2009). “Differences between peptic ulcer between the east and the west”, Gastroenterol Clinic North America, Vol.38, pp.363-379.
Marshall BJ, and Warren JR. (1984). “Unidentified curved bacilli in the stomach of patients with Gastritis and peptic ulceration”, The Lancet, Jun 16, Vol.1, pp.1311-1315.
Mustapha SK, Ajaji NA, Nggada HA, Pindiga UH, Bolori MT, and Ndahi A. (2007).” Endoscopic findings and the frequency of H. pylori among Dyspeptic patients in Maiduguri Northeastern Nigeria”, Highland Medical Research Limited, Vol.5(1), pp.78-81.
Parente JML, Da Silva BB, Palha-Dias MPS, Zaterka S, Nishimura NF, and Zeitue JM. (2006). “Helicobacter Pylori Infection in Children of Low and High Socioeconomic Status in Northeastern Brazil”, The American Journal of Tropical Medicine and Hygeine, Vol.75(3), pp.509-512.
Perri F, and Festa V, et al. (2003). “Dyspepsia and Helicobacter pylori infection: a prospective multicentric observational study v”, Digestive and Liver Disease, Mar, Vol.35(3), pp.157-164.
Rodrigues MN, Queiroz DMM, and Rodrigues RT, et al. (2005). “Helicobacter pylori Infection in Adults from a Poor Urban Community in Northeastern Brazil: Demographic, Lifestyle and Environmental Factors”, The Brazilian Journal of Infectious Diseases, Vol.9(5), pp.405-410.
Taylor DN, and Blaser MJ. (1991). “The epidemiology of Helicobacter pylori infection”, Epidemiol Rev, Vol.13(1991), pp.42-59.
Refbacks
- There are currently no refbacks.
Send mail to ijsss@ijsss.com with questions or comments about this web site.
International Journal of Surgery and Surgical Sciences, All rights reserved.